Evaluation of cytotoxic activity of marine fungi isolated from sponges in Nha Trang bay
نویسندگان
چکیده
Marine fungi are evaluated as a potential source for new natural compounds with bioactivities of pharmaceutical values. In this study, 66 fungal strains, isolated from 37 sponge samples in Nha Trang bay, were determined cytotoxic activity against two human cancer cell lines, including cervical (Hela) and breast (MCF-7) cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The results showed that 46.9% (31/66) strains exhibited both test lines. Based on the internal transcribed spacer (ITS) gene sequences analysis, five isolates significant anticancer identified Aspergillus sp. 1901NT-1.2.2, Talaromyces 1901NT-1.39.3, subramanianii 1901NT-1.40.2, Phoma 1901NT-1.45.1, Penicillium 1901NT-2.53.1. Our finding indicated sponge-derived bay might be need further study to discover drugs.
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ژورنال
عنوان ژورنال: T?p chí Khoa h?c và Công ngh? Bi?n
سال: 2022
ISSN: ['1859-3097']
DOI: https://doi.org/10.15625/1859-3097/16631